Dunno if I shuold put spoilers for this, but just in case.
According to *clenched teeth* Simone,
1. Rogue's gonna suffer a tragedy in #3, which has lead speculation for Gambit to die. Unlikely because 2. "People who hate Gambit will love him in #5" (paraphrasing), so he's alive up to that number.
Some of the speculation is
1. The cats die (doubtful, that'd be Gambit's, not Rogue's tragedy. Same for anyone from NO)
2. A young mutant dies (I think this is the most likely, although how much of a tragedy for Rogue this can be and not for Logan or Gambit?
3. Miscarriage (I'll hate Simone for the rest of my life if so. Not very likely, tbf).