I'm glad she addressed it and that's kind of how I read into it as well. Remy's probably a little jealous but doesn't let it get to him because he's, in the long-run, better than Deadpool in the romantic sense. Plus, he got the girl.
Plus, as Gambit pointed out, he has a face. :D
I have faith in KT's ability to pull off the storyline, and keep it fun. I've genuinely liked everything she's written in comics. She got me into Jem, which I picked up on a whim from the library and really enjoyed.
My somewhat sceptical sense is that Deadpool might be editorially mandated, though. You have a new book, which you want to get sales. Deadpool is huge at the moment both in and out of hard-core fandom. You're going to find a way to get him on the cover of as many books as possible.
As others have said, I would totally have him hit on Rogue and get shot down, and then shrug and hit on Gambit. You know Wade would.